ABSTRACT
BACKGROUND: We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes. CASE: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers. DISCUSSION AND CONCLUSION: Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.
Subject(s)
Antibodies, Neutralizing/blood , Antibodies, Viral/blood , COVID-19/immunology , Immunoglobulin G/blood , Infectious Disease Transmission, Patient-to-Professional , SARS-CoV-2/immunology , Adult , Antibodies, Neutralizing/biosynthesis , COVID-19/transmission , Cross Infection/immunology , Enzyme-Linked Immunosorbent Assay , Female , Humans , Immunoglobulin G/biosynthesis , Male , Middle Aged , Nasopharynx/virology , SARS-CoV-2/classification , SARS-CoV-2/geneticsSubject(s)
Antibodies, Viral/blood , COVID-19/epidemiology , COVID-19/immunology , Cross Infection/prevention & control , Immunoglobulin G/blood , Personnel, Hospital/statistics & numerical data , Adult , Aged , Aged, 80 and over , Cross Infection/immunology , Cross Infection/virology , Female , Hospitals, General/statistics & numerical data , Humans , Infection Control , Male , Middle Aged , Retrospective Studies , SARS-CoV-2/immunology , Seroepidemiologic Studies , Young AdultABSTRACT
Solid organ transplant recipients are considered at high risk for COVID-19 infection due to chronic immune suppression; little data currently exists on the manifestations and outcomes of COVID-19 infection in lung transplant recipients. Here we report 8 cases of COVID-19 identified in patients with a history of lung transplant. We describe the clinical course of disease as well as preexisting characteristics of these patients.